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  • A carcinoma occurring almost exclusively in adults that probably arises from the pancreatic duct epithelium. Most pancreatic carcinomas are ductal adenocarcinomas of which about two-thirds involve the head, with the remainder in the body and tail of the pancreas. The patients are usually over 50 years of age. Pain, jaundice, and loss of weight are the most common manifestations. Ductal adenocarcinomas usually grow rapidly and are discovered after they have already spread beyond the pancreas. Grossly, ductal adenocarcinomas are firm and poorly defined masses. Microscopically, most ductal adenocarcinomas are characterized by well-developed glandular structures embedded in a desmoplastic stroma. Ductal adenocarcinomas are fatal in the vast majority of cases (WHO 2000). Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9120\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C9120\' NCI Thesaurus)
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