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Stage III includes: (T1, T2, N1, M0); (T1, T2, N2, M0); (T3, N0, N1, N2, M0). T1: pleural mesothelioma with a tumor limited to the ipsilateral parietal pleura with or without mediastinal pleura and with or without diaphragmatic pleural involvement. T2: pleural mesothelioma with a tumor involving each of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following: involvement of diaphragmatic muscle; extension of tumor from visceral pleura into the underlying pulmonary parenchyma. T3: pleural mesothelioma with a locally advanced but potentially respectable tumor. Tumor involving all the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following: involvement of the endothoracic fascia; extension into the mediastinal fat; solitary, completely respectable focus of tumor extending into the soft tissues of the chest wall; nontransmural involvement of the pericardium. N0: no regional lymph node metastasis. N1: pleural mesothelioma with metastases in the ipsilateral bronchopulmonary or hilar lymph nodes. N2: pleural mesothelioma with metastases in the subcarinal or the ipsilateral mediastinal lymph nodes including the ipsilateral internal mammary and peridiaphragmatic nodes. M0: no distant metastasis. (AJCC 7th ed.) Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C6648\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C6648\' NCI Thesaurus)
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