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  • A fusion gene that results from a chromosomal translocation t(7;21)(p21;q22) which fuses the 5\' end of the TMPRSS2 gene with exon 4 of the ETV1 gene. This rearrangement is associated with prostate carcinoma and androgen-dependent expression of this fusion gene results in overexpression of ETS translocation variant 1 protein activity.
  • A fusion gene that results from a genetic translocation event which fuses the 5\' end of the androgen-regulated TMPRSS2 gene with the entire coding region of the ERG gene. The androgen-dependent expression of this fusion gene results in overexpression of ERG activity.
  • This gene plays a role in the activation of pathway signaling.
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