C1511005_NCI_BioC | Knowledge4COVID-19

Property	Value
?:definition	Physical interactions between integrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, survivin, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction. (This definition may be outdated - see the DesignNote.)
?:hasCUIAnnotation	<https://research.tib.eu/covid-19/entity/C1511005>
?:hasGeneratedBy	<https://research.tib.eu/covid-19/SourceName/NCI_BioC>
?:type	<https://research.tib.eu/covid-19/vocab/AnnotationDefinition>

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