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Derived by Little (1921) from A Lathrop stocks and separated out before 1937, the C57BL/10 mouse has a black coat and carries a Y chromosome of Asian Mus musculus origin and a LINE-1 element from Mus spretus. Substrain C57BL/10 differs from other substrains at multiple loci, including H9, Igh2 and Lv, on chromosome 4 and has a high incidence of spontaneous mutations.
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