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  • The type 4 form of EWS/FLI-1, an oncogenic fusion gene found in Ewing\'s sarcoma and primitive neuro-ectodermal tumor (PNET). Resulting from a t(11;22) chromosomal translocation, EWS/FLI 1 appears to play an integral role in the development of Ewing\'s sarcoma and PNET; the type 4 form of this gene has been shown to transform non-neoplastic cells. EWS/FLI 1 type 4 represents a potential target for antisense oligonucleotide therapy of Ewing\'s sarcoma and PNET. (NCI04)
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