C1513089_NCI_BioC | Knowledge4COVID-19

Property	Value
?:definition	Studies with homozygous knockout mice have suggested that stem cell factor (SCF or KITLG), c-Kit, microphthalmia (Mitf), and B-cell CLL/lymphoma 2 (Bcl2) genes regulate melanocytic development. The SCF activation of Kit receptor leads to Mitf phosphorylation through the MAP kinase pathway. The activated Mitf recruits p300 and up-regulates Bcl2 transcription, which plays an important role in modulating the development and survival of the melanocyte lineage. (This definition may be outdated - see the DesignNote.)
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