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  • A recombinant monoclonal antibody (OVB3) directed against human ovarian cancer linked with an exotoxin derived from the bacterium Pseudomonas aeruginosa. The antibody portion of the agent binds to human ovarian cancer cells; the pseudomonas exotoxin, a 66 kDa protein belonging to a family of enzymes known as mono-(ADP-ribosyl) transferases, stops tumor cell protein synthesis by inactivating elongation factor 2 and disrupting protein synthesis.. (NCI04)
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