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  • A murine monoclonal antibody directed against the human epidermal growth factor receptor (EGFR). Monoclonal antibody RG 83852 binds to the EGFR, inhibiting the high-affinity binding of epidermal growth factor (EGF) and receptor activation. Overexpression of EGFR, a tyrosine kinase, and its upregulated activity have been implicated in the pathogeneses of several malignancies. (NCI04)
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