C1515053_NCI_BioC | Knowledge4COVID-19

Property	Value
?:definition	Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptional repression. (This definition may be outdated - see the DesignNote.)
?:hasCUIAnnotation	<https://research.tib.eu/covid-19/entity/C1515053>
?:hasGeneratedBy	<https://research.tib.eu/covid-19/SourceName/NCI_BioC>
?:type	<https://research.tib.eu/covid-19/vocab/AnnotationDefinition>

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