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  • The reciprocal product of T-cell receptor (TCR) gene rearrangement. Following TCR gene rearrangement the T-cell receptor excision circle (TREC) is maintained in the cell as a non-replicating episome. With each cell division the TREC is segregated to a single daughter cell and becomes diluted in the population. Recent TCR rearrangement can be detected by a spike in the number of TREC and can be used to quantify thymic T-cell output.
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