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  • The spontaneous hypertensive rat was derived by Okamoto at the Kyoto school of medicine (1963) from a cross between an outbred Wistar Kyoto male with a significant elevation of blood pressure and a female Wistar Kyoto with elevated blood pressure. SHR rats develop hypertension spontaneously without exception at the age of 7-15 weeks with a systolic blood pressure plateau of about 200 mmHg. The genetic basis is polygenic, with at least three major genes involved (Tanase and Suzuki 1971, Yen et al 1974).
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