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  • A galectin-binding polysaccharide derived from citrus pectin with potential antineoplastic activity. Apoptosis inducer GCS-100 binds to the carbohydrate-binding domain of the lectin galectin-3, which may result in apoptosis mediated through mitochondria/caspase activation cascades; this agent may overcome tumor growth mediated through anti-apoptotic protein Bcl-2, heat shock protein-27 (Hsp-27), and nuclear factor-kappa B (NF-kB). Galectin-3, a chimeric molecule consisting of bothcarbohydrate recognition and collagen-like domains, interacts with a variety of carbohydrate andprotein ligands to form pentamers with uniquecrosslinking abilities; this lectin also exhibits anti-apoptotic properties, perhaps, in part, through the regulation of intracellular signaling pathways. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C70984\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C70984\' NCI Thesaurus)
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