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Human ERBB3 wild-type allele is located within 12q13 and is approximately 23 kb in length. This allele, which encodes receptor tyrosine-protein kinase erbB-3 protein, is involved in the regulation of celullar proliferation and differentiation. Amplification or overexpression of this gene, has been documented in several solid tumors and cancers, including prostate, bladder, and breast.
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