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  • Human AFF4 wild-type allele is located in the vicinity of 5q31 and is approximately 88 kb in length. This allele, which encodes AF4/FMR2 family member 4 protein, is involved in transcriptional regulation. A chromosomal aberration involving this gene and the MLL gene, insertion ins(5;11)(q31;q13q23), is associated with acute lymphoblastic leukemia.
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