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  • Human ACKR2 wild-type allele is located in the vicinity of 3p21.3 and is approximately 58 kb in length. This allele, which encodes atypical chemokine receptor 2 protein, is involved in the recruitment of effector immune cells to sites of inflammation. The allele also plays a role in chemokine-driven leukocytes recirculation. Variant alleles have been implicated in chemokine effects relating to the development and growth of vascular tumors.
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