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  • Human FLI1 wild-type allele is located within 11q24.1-q24.3 and is approximately 118 kb in length. This allele, which encodes Friend leukemia integration 1 transcription factor protein, plays a role in the activation of transcription by RNA polymerase II. Ewing sarcoma is linked to the chromosomal translocation t(11;22)(q24;q12) of the EWSR1 gene and the FLI1 gene.
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