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  • Human IRAK2 wild-type allele is located in the vicinity of 3p25.3 and is approximately 74 kb in length. This allele, which encodes interleukin-1 receptor-associated kinase-like 2 protein, plays a role both in interleukin-1-induced up-regulation of the transcription factor NF-kappa B and in regulation of responsiveness to bacterial endotoxins.
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