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  • Human YES1 wild-type allele is located within 18p11.31-p11.21 and is approximately 91 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase Yes protein, plays a role in signal transduction pathways involved in the formation of adherins junctions and gap junctions between cells. Expression of the YES1 gene is up-regulated in colon cancer from patients with inflammatory bowel disease.
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