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  • Catalysis of the removal of oxidized purine bases by cleaving the N-C1\' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3\' of the apurinic (AP) site. [GOC:elh, PMID:11554296]
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