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  • A pegylated, cross-linked, humanized divalent-Fab\' antibody fragment directed against vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic and antitumor activities. Pegylated anti-GFR antibody fragment binds to and inhibits VEGFR-2, which may inhibit angiogenesis and tumor cell proliferation. Multivalent Fab\' antibody fragments may exhibit improved retention and internalization properties compared to their parent IgGs. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61438\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61438\' NCI Thesaurus)
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