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  • A vaccine consisting of the melanocyte differentiation antigen Melan A (also called MART-1) encapsulated in noninfectious virus-like particles (VLPs) with potential immunostimulating and antineoplastic activities. Upon administration, Melan-A VLP vaccine may stimulate the immune system to exert a specific cytotoxic T lymphocyte (CTL) response against tumor cells expressing the Melan A antigen, resulting in tumor cell lysis. Melan A is upregulated in most melanomas. VLPs stimulate the immune system and promotes the CTL response. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61495\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61495\' NCI Thesaurus)
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