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  • Myopathy is a disorder of striated muscle, with or without changes in muscle mass, and may be accompanied by muscle pain or tenderness. Rhabdomyolysis results from extensive necrosis of skeletal muscle with release of muscle contents and can be related to hereditary metabolic or structural abnormalities effecting skeletal muscle cells or non-hereditary causes such as (e.g., trauma). Muscle signs and symptoms include pain, weakness, tenderness, and contractures, weight gain, fatigue, malaise, fever, nausea, tachycardia, and dark urine. Potentially serious sequelae include acute renal failure, compartment syndrome, disseminated intravascular coagulation, cardiomyopathy, and respiratory failure.
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