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  • Acute renal failure (ARF) is characterized by a relatively rapid decline in renal function that leads to the accumulation of water, crystalloid solutes, and nitrogenous metabolites in the body. Other clinical features include: increase in serum creatinine and urea nitrogen levels (azotemia) greater than 0.5 and 10 mg per deciliter, respectively; oliguria; and changes in the rate of urine flow. ARF may present with a de novo onset in individuals whose baseline renal function was within normal limits. Additionally, ARF may consist of acute exacerbation of pre-existing chronic renal insufficiency.
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