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  • Drug-induced pancreatitis is usually an acute condition. If clinically suspected, it should always be confirmed by biochemical investigations - Definition of acute pancreatitis: o An inflammatory disease of the pancreas characterized by upper abdominal pain and vomiting; in severe cases - abdominal guarding, rigidity, rebound tenderness and diminution or loss of bowel sounds o Almost always accompanied by increased pancreatic enzymes - amylase and lipase - in the blood and urine o Other signs/findings are icterus, increased alkaline phosphatase and/or bilirubin, ileus, ascites, hyperglycemia, hypocalcemia and leukocytosis o Cullen\'s sign is sometimes associated with severe necrotizing pancreatitis - Severe attacks may lead to shock with renal and pulmonary insufficiency, which may be fatal.
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