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  • Agranulocytosis can occur as a reaction to a wide variety of toxic agents (including drugs - Life-threatening due to increased susceptibility to infection - Overall annual incidence less than 1:100,000 in the general population - Severe neutropenia (< 0.5 x 109/l of circulating granulocytes) associated with the sudden onset of signs and symptoms of bacterial infection o fever, malaise and prostration o oropharyngeal or anorectal lesions
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