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  • In the CIOMS publication on definitions of terms and criteria for their use, definitions for aplastic anaemia, agranulocytosis, bone marrow depression, granulocytopenia, leucopenia, neutropenia, and pancytopenia are provided. However, it was not possible to strictly follow those definitions. The definitions in the CIOMS publication include signs and symptoms of cytopenic conditions. The respective signs and symptoms, however, are in such a way unspecific (e.g. headache, pallor, malaise, infections etc.) that it did not seem worthwhile to include them in an SMQ, nor in a broad subgroup. Furthermore, the definitions include distinct ranges of lab values which are not reflected in MedDRA.
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