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  • A proprietary agent with potential antineoplastic activity. Cell cycle checkpoint/DNA repair antagonist IC83 IC83 inhibits cell cycle checkpoint/DNA repair enzymes, which may result in enhanced cytotoxicity of DNA damaging agents and diminished tumor cell resistance to chemotherapy and radiation therapy.Cell cycle checkpoint/DNA repair enzymes are involved in the recognition and repair of damaged DNA and are overexpressed in many types of cancer cells. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C67075\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C67075\' NCI Thesaurus)
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