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  • An attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with potential gene expression and antineoplastic activities. After attachment to and fusion with host tumor cell membranes, MV-NIS may induce tumor cell syncytia and tumor cell lysis. When combined with iodine 123 (I-123), expressed NIS facilitates uptake of I-123 by MV-NIS-infected tumor cells, allowing noninvasive imaging of these cells. MV-NIS may also enhance the oncolytic activity of MV against radiosensitive tumor cells by facilitating the uptake of iodine 131 (I-131) by MV-NIS-infected cells. The cellular receptor for MV is the human CD46 antigen, a type 1 integral membrane glycoprotein found on nearly all human tissues and overexpressed on many cancer cell types. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66942\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66942\' NCI Thesaurus)
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