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  • A synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs.AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C70655\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C70655\' NCI Thesaurus)
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