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  • A computer-implemented image processing method and apparatus for normalizing gel electrophoresis images. The method includes the steps of assigning tiepoints in a reference image and in one or more object images. The tiepoints in the object image are evaluated by comparison to a corresponding tiepoint in the reference image, and the location of the tiepoint in the object image is adjusted by slight movement to a location with respect to recognizable features in both the reference and object image. Warping functions are generated and then globally optimized.
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