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Most common cause of reduced vision (particularly cataracts). Responsible for about 35% of cases of visual impairment. Cataracts: may result from a number of processes (mainly age-related); usually progress slowly, but frequently only detected when reach a certain level of severity, or during opthalmological examination; symptoms often subtle (e.g., yellow vision) and often an anatomically severe cataract will not be associated with an equally severe functional loss of vision; symptoms may include glare, blurred vision, altered color perception, change of refraction, and monocular diplopia. A \'sudden appearance\' reported as an adverse event could actually result from a pre-existing condition. Care should be taken in evaluating apparent association between these lesions and drug therapy. Definitions (from multiple sources): Aphakia: absence of lens; may occur congenitally or from trauma, but is most commonly caused by extraction of a cataract; cataract: congenital or acquired lack of clarity of the lens; clouding of the lens; opacity of lens or capsule of eye causing impairment of vision or blindness.
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