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Any agents that inhibit mTOR (FK506 binding protein 12-rapamycin associated protein 1), one of the protein kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. mTOR acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2201\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2201\' NCI Thesaurus)
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