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  • A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5\' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5\' and 3\' splice sites occurs at the time of prespliceosome formation. [GOC:ab, GOC:krc, GOC:mah, PMID:10197985, PMID:16201866]
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