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  • A cancer vaccine containing autologous dendritic cells electroporated with full-length mRNA encoding Wilms\' tumor 1 (WT1) antigen with potential immunostimulatory and antineoplastic activities. Upon administration, WT1 mRNA-electroporated autologous dendritic cell vaccine may elicit a cytotoxic T-cell (CTL) response against tumor cells expressing WT1. Wt1 is frequently overexpressed in a variety of tumor cell types and often correlates with disease progression and poor prognosis. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88260\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C88260\' NCI Thesaurus)
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