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  • A hapten-carrier immunoconjugate composed of the hapten trans-3\'-aminomethyl nicotine conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through amino acid depletion, with potential immunostimulating activity. Upon vaccination with 3\'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small organic molecule that is notimmunogenic, must be haptenized and conjugated to a carrierprotein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody response. Aluminiumhydroxide may be used as an adjuvant for this vaccine. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88341\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C88341\' NCI Thesaurus)
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