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  • An implant containing a sustained release particle of fluorouracil, an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine, with antineoplastic activity. Upon implantation and subsequent release, fluorouracil is converted into the active metabolite 5-fluoroxyuridine monophosphate that competes with the pyrimidine uracil during RNA synthesis while another active metabolite, 5-5-fluoro-2\'-deoxyuridine-5\'-O-monophosphate, inhibits thymidylate synthase and thus DNA synthesis. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90544\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C90544\' NCI Thesaurus)
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