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  • Human ATF1 wild-type allele is located in the vicinity of 12q13.12 and is approximately 57 kb in length. This allele, which encodes cyclic AMP-dependent transcription factor ATF-1 protein, plays a role in transcriptional regulation. Two translocations of this gene are associated with angiomatoid fibrous histiocytoma and clear cell sarcoma. Translocation t(12;16)(q13;p11.2) with the FUS gene and t(12;22)(q13;q12) with the EWSR1 gene are expressed as fusion proteins.
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