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  • Human MTDH wild-type allele is located in the vicinity of 8q22.1 and is approximately 86 kb in length. This allele, which encodes protein LYRIC, plays a role in transcriptional regulation, promotion of tumor cell anchorage-independent growth and metastasis. Aberrant expression is associated with prostate cancer and hepatocellular carcinomas. Genetic variation may be associated with migraine.
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