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  • Human TRIM21 wild-type allele is located in the vicinity of 11p15.5 and is approximately 9 kb in length. This allele, which encodes E3 ubiquitin-protein ligase TRIM21 protein, plays a role in the regulation of both cell cycle progression and ubiquitinylation of proteins. Polymorphism of the gene is associated with systemic lupus erythematosus.
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