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  • A humanized IgG1 monoclonal antibody targeting the T-cell differentiation antigen CD6, with immunmodulating activity. Itolizumab binds to CD6, downregulates the activation and differentiation of T cells, prevents CD6-mediated activation pathways and reduces the synthesis of pro-inflammatory cytokines. CD6, a co-stimulatory molecule predominantly expressed on lymphocytes, is involved in the adhesion and maturation of T cells.
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