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  • A humanized monoclonal antibody targeting the beta7 subunit of the heterodimeric integrins alpha4beta7 and alphaEbeta7, with anti-inflammatory activity. Etrolizumab binds to the beta subunit of the alpha4beta7 and alphaEbeta7 integrins in the gastronintestinal tract blocking their activity. This prevents integrin-mediated leukocyte migration to and accumulation in sites of inflammation.
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