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  • A recombinant form of human complement component 1 esterase inhibitor (C1INH), a serine protease inhibitor normally present in human plasma, that can be used for the treatment of hereditary angioedema (HAE). Upon administration, conestat alfa irreversibly binds to and inhibits the activities of several proteases of the contact and complement systems, which may include activated C1s, kallikrein, factor XIIa and factor XIa, blocking the activation of the contact and complement systems. This may prevent inflammation and the production of bradykinin (BK), thereby blocking BK-driven increase in vascular permeability and the resulting edema.
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