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Knives designed to cut in-vivo a sample of tissue from an anatomic structure of the body that is intended for laboratory examination and/or test (i.e., biopsy). These knives are typically manual, handheld instruments with a straight handle and a blade with a sharp convex edge. Biopsy knives include instruments of a variety of shapes and sizes according to the tissue to be cut and/or the biopsy procedure to be performed. Dedicated biopsy knives (known as cone knives) are used to collect tissue specimens from the uterine cervix
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