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  • Human NSD3 wild-type allele is located in the vicinity of 8p11.23 and is approximately 113 kb in length. This allele, which encodes histone-lysine N-methyltransferase NSD3 protein, plays a role in the regulation of histone methylation. A chromosomal translocation t(8;11)(p11;p15) involving the NUP98 gene and this gene is associated with acute myeloid leukemia.
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