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  • Human CBFA2T3 wild-type allele is located in the vicinity of 16q24 and is approximately 102 kb in length. This allele, which encodes protein CBFA2T3, is involved in the repression of transcription. A translocation t(16;21)(q24;q22) of this gene and the RUNX1 gene is associated with acute myeloid leukemia.
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