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Human HLF wild-type allele is located in the vicinity of 17q22 and is approximately 60 kb in length. This allele, which encodes hepatic leukemia factor, plays a role in the modulation of transcription. A chromosomal translocation t(17;19)(q22;p13.3) with the TCF3 gene is associated with childhood pre-B-cell acute lymphoblastic leukemia.
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