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  • Systems designed for minimally invasive treatment of diseases by applying cold at temperatures below the freezing point of water (i.e., less than zero degrees Celsius/32 degrees Fahrenheit). These systems typically consist of a unit that provides the cryogenic substance (e.g., carbon dioxide, liquid nitrogen, argon, helium) and a delivery system that may include applicators, needles, cannulae, or catheters; the type of cryogen used and the configuration of the delivery system depend on the intended use.
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