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?:definition
  • Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT (signal transducer and activator of transcription) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes. [GOC:bf]
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