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  • A non-immune hypersensitivity reaction directed towards a foreign substance, which results in tissue injury, which is usually transient. It is the manifestation of the pseudoallergic state.
  • A nonimmune hypersensitivity reaction directed towards a foreign substance, which results in tissue injury, which is usually transient. It is the manifestation of the pseudoallergic state.
  • A pathological nonimmune process generally directed towards a foreign substance, which results in tissue injury, which is usually transient. It is the realization of the pseudoallergic disposition. A variety of mechanisms such as direct histamine release, complement activation, cyclooxygenase activation and bradykinin generation may be involved.
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